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Automatic Chemotaxis

Chemotaxis is the phenomenon in which cells, bacteria, and other cell organisms direct their movements according to certain chemicals in their immediate environment.

Examples of this phenomenon are when certain bacteria types navigate towards nutrition, and when white blood cells locate threats to the human body.


 

 

 

 

 

Unisensors core technology FluidScope™, which lies at the heart of the oCelloScope™ instrument, enables research within chemotaxis processes.

The enabling technique is the fundamental capability of tracking objects (cells) in 3 dimensions from timelapse imaging of the sample.

From the traces of each object information such as:

  • mean velocity
  • directedness
  • cell division rates

can be assessed for both individual cells and the population as a whole.

Below an example of E-coli bacteria development is presented.

Distribution of track displacements

The example given here shows activated dendritic cells on a microscope slide. A drop of Fibronectin, which attracts the dendritic cells, is placed inside the ring in the lower left hand corner. The distribution of track displacements in the polar histogram above shows a clear overall movement towards the Fibronection in the lower left hand corner.

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Press Release from HTF: Danish technology creates revolution in the fight against multi-resistant bacteria.
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