Examples of this phenomenon are when certain bacteria types navigate towards nutrition, and when white blood cells locate threats to the human body.
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Unisensors core technology FluidScope™, which lies at the heart of the oCelloScope™ instrument, enables research within chemotaxis processes.
The enabling technique is the fundamental capability of tracking objects (cells) in 3 dimensions from timelapse imaging of the sample.
From the traces of each object information such as:
can be assessed for both individual cells and the population as a whole.
Below an example of E-coli bacteria development is presented. |
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The example given here shows activated dendritic cells on a microscope slide. A drop of Fibronectin, which attracts the dendritic cells, is placed inside the ring in the lower left hand corner. The distribution of track displacements in the polar histogram above shows a clear overall movement towards the Fibronection in the lower left hand corner. |